Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

An antibiotic from an uncultured bacterium binds to an immutable target.

Shukla, Rhythm; Peoples, Aaron J; Ludwig, Kevin C; Maity, Sourav; Derks, Maik G N; De Benedetti, Stefania; Krueger, Annika M; Vermeulen, Bram J A; Harbig, Theresa; Lavore, Francesca; Kumar, Raj; Honorato, Rodrigo V; Grein, Fabian; Nieselt, Kay; Liu, Yangping; Bonvin, Alexandre M J J; Baldus, Marc; Kubitscheck, Ulrich; Breukink, Eefjan; Achorn, Catherine; Nitti, Anthony; Schwalen, Christopher J; Spoering, Amy L; Ling, Losee Lucy; Hughes, Dallas; Lelli, Moreno; Roos, Wouter H; Lewis, Kim; Schneider, Tanja; Weingarth, Markus.

Cell ; 186(19): 4059-4073.e27, 2023 09 14.

Artigo em Inglês | MEDLINE | ID: mdl-37611581

2.

A selective antibiotic for Lyme disease.

Leimer, Nadja; Wu, Xiaoqian; Imai, Yu; Morrissette, Madeleine; Pitt, Norman; Favre-Godal, Quentin; Iinishi, Akira; Jain, Samta; Caboni, Mariaelena; Leus, Inga V; Bonifay, Vincent; Niles, Samantha; Bargabos, Rachel; Ghiglieri, Meghan; Corsetti, Rachel; Krumpoch, Megan; Fox, Gabriel; Son, Sangkeun; Klepacki, Dorota; Polikanov, Yury S; Freliech, Cecily A; McCarthy, Julie E; Edmondson, Diane G; Norris, Steven J; D'Onofrio, Anthony; Hu, Linden T; Zgurskaya, Helen I; Lewis, Kim.

Cell ; 184(21): 5405-5418.e16, 2021 10 14.

Artigo em Inglês | MEDLINE | ID: mdl-34619078

3.

The Science of Antibiotic Discovery.

Lewis, Kim.

Cell ; 181(1): 29-45, 2020 04 02.

Artigo em Inglês | MEDLINE | ID: mdl-32197064

4.

Teixobactin kills bacteria by a two-pronged attack on the cell envelope.

Shukla, Rhythm; Lavore, Francesca; Maity, Sourav; Derks, Maik G N; Jones, Chelsea R; Vermeulen, Bram J A; Melcrová, Adéla; Morris, Michael A; Becker, Lea Marie; Wang, Xiaoqi; Kumar, Raj; Medeiros-Silva, João; van Beekveld, Roy A M; Bonvin, Alexandre M J J; Lorent, Joseph H; Lelli, Moreno; Nowick, James S; MacGillavry, Harold D; Peoples, Aaron J; Spoering, Amy L; Ling, Losee L; Hughes, Dallas E; Roos, Wouter H; Breukink, Eefjan; Lewis, Kim; Weingarth, Markus.

Nature ; 608(7922): 390-396, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35922513

5.

The antibiotic darobactin mimics a ß-strand to inhibit outer membrane insertase.

Kaur, Hundeep; Jakob, Roman P; Marzinek, Jan K; Green, Robert; Imai, Yu; Bolla, Jani Reddy; Agustoni, Elia; Robinson, Carol V; Bond, Peter J; Lewis, Kim; Maier, Timm; Hiller, Sebastian.

Nature ; 593(7857): 125-129, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33854236

6.

Author Correction: A new antibiotic selectively kills Gram-negative pathogens.

Imai, Yu; Meyer, Kirsten J; Iinishi, Akira; Favre-Godal, Quentin; Green, Robert; Manuse, Sylvie; Caboni, Mariaelena; Mori, Miho; Niles, Samantha; Ghiglieri, Meghan; Honrao, Chandrashekhar; Ma, Xiaoyu; Guo, Jason J; Makriyannis, Alexandros; Linares-Otoya, Luis; Böhringer, Nils; Wuisan, Zerlina G; Kaur, Hundeep; Wu, Runrun; Mateus, André; Typas, Athanasios; Savitski, Mikhail M; Espinoza, Josh L; O'Rourke, Aubrie; Nelson, Karen E; Hiller, Sebastian; Noinaj, Nicholas; Schäberle, Till F; D'Onofrio, Anthony; Lewis, Kim.

Nature ; 580(7802): E3, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-32269338

7.

A new antibiotic selectively kills Gram-negative pathogens.

Imai, Yu; Meyer, Kirsten J; Iinishi, Akira; Favre-Godal, Quentin; Green, Robert; Manuse, Sylvie; Caboni, Mariaelena; Mori, Miho; Niles, Samantha; Ghiglieri, Meghan; Honrao, Chandrashekhar; Ma, Xiaoyu; Guo, Jason J; Makriyannis, Alexandros; Linares-Otoya, Luis; Böhringer, Nils; Wuisan, Zerlina G; Kaur, Hundeep; Wu, Runrun; Mateus, André; Typas, Athanasios; Savitski, Mikhail M; Espinoza, Josh L; O'Rourke, Aubrie; Nelson, Karen E; Hiller, Sebastian; Noinaj, Nicholas; Schäberle, Till F; D'Onofrio, Anthony; Lewis, Kim.

Nature ; 576(7787): 459-464, 2019 12.

Artigo em Inglês | MEDLINE | ID: mdl-31747680

8.

Deletions of DNA in cancer and their possible uses for therapy.

Varshavsky, Alexander; Lewis, Kim; Chen, Shun-Jia.

Bioessays ; 45(7): e2300051, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37166062

9.

An Approach to Diversifying the Selection of a Guideline Panel-The Process Utilized for the Updated Adult Critical Care Ultrasound Guidelines.

Nikravan, Sara; Lanspa, Michael J; Ablordeppey, Enyo; Gerlach, Anthony T; Shutter, Lori; Patel, Hariyali; Reuter-Rice, Karin; Lewis, Kim; Sharif, Sameer; Díaz-Gómez, José L.

Crit Care Med ; 2024 Apr 08.

Artigo em Inglês | MEDLINE | ID: mdl-38587423

10.

Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis.

Imai, Yu; Hauk, Glenn; Quigley, Jeffrey; Liang, Libang; Son, Sangkeun; Ghiglieri, Meghan; Gates, Michael F; Morrissette, Madeleine; Shahsavari, Negar; Niles, Samantha; Baldisseri, Donna; Honrao, Chandrashekhar; Ma, Xiaoyu; Guo, Jason J; Berger, James M; Lewis, Kim.

Nat Chem Biol ; 18(11): 1236-1244, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-35996001

11.

Bacterial persisters are a stochastically formed subpopulation of low-energy cells.

Manuse, Sylvie; Shan, Yue; Canas-Duarte, Silvia J; Bakshi, Somenath; Sun, Wei-Sheng; Mori, Hirotada; Paulsson, Johan; Lewis, Kim.

PLoS Biol ; 19(4): e3001194, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33872303

12.

Persister Awakening.

Lewis, Kim; Shan, Yue.

Mol Cell ; 63(1): 3-4, 2016 07 07.

Artigo em Inglês | MEDLINE | ID: mdl-27392143

13.

Characterization of a Radical SAM Oxygenase for the Ether Crosslinking in Darobactin Biosynthesis.

Nguyen, Hai; Made Kresna, I Dewa; Böhringer, Nils; Ruel, Jeremie; Mora, Eugenio de la; Kramer, Jil-Christine; Lewis, Kim; Nicolet, Yvain; Schäberle, Till F; Yokoyama, Kenichi.

J Am Chem Soc ; 144(41): 18876-18886, 2022 10 19.

Artigo em Inglês | MEDLINE | ID: mdl-36194754

14.

Bacterial persisters in long-term infection: Emergence and fitness in a complex host environment.

Bartell, Jennifer A; Cameron, David R; Mojsoska, Biljana; Haagensen, Janus Anders Juul; Pressler, Tacjana; Sommer, Lea M; Lewis, Kim; Molin, Søren; Johansen, Helle Krogh.

PLoS Pathog ; 16(12): e1009112, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33315938

15.

Predicting antimicrobial mechanism-of-action from transcriptomes: A generalizable explainable artificial intelligence approach.

Espinoza, Josh L; Dupont, Chris L; O'Rourke, Aubrie; Beyhan, Sinem; Morales, Pavel; Spoering, Amy; Meyer, Kirsten J; Chan, Agnes P; Choi, Yongwook; Nierman, William C; Lewis, Kim; Nelson, Karen E.

PLoS Comput Biol ; 17(3): e1008857, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33780444

16.

Streptonigrin kills bacteria by stealth.

Lewis, Kim.

Proc Natl Acad Sci U S A ; 121(4): e2320942121, 2024 Jan 23.

Artigo em Inglês | MEDLINE | ID: mdl-38227663

17.

Total Synthesis of Kibdelomycin.

He, Chi; Wang, Yu; Bi, Cheng; Peters, David S; Gallagher, Timothy J; Teske, Johannes; Chen, Jason S; Corsetti, Rachel; D'Onofrio, Anthony; Lewis, Kim; Baran, Phil S.

Angew Chem Int Ed Engl ; 61(32): e202206183, 2022 08 08.

Artigo em Inglês | MEDLINE | ID: mdl-35704446

18.

Point-of-care ultrasound training for respiratory therapists: A scoping review.

Kappel, Coralea; Chaudhuri, Dipayan; Hassall, Kelly; Theune, Shannon; Sharif, Sameer; Alhazzani, Waleed; Lewis, Kim.

Can J Respir Ther ; 58: 28-33, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35359818

19.

Optimization of heterologous Darobactin A expression and identification of the minimal biosynthetic gene cluster.

Wuisan, Zerlina G; Kresna, I Dewa M; Böhringer, Nils; Lewis, Kim; Schäberle, Till F.

Metab Eng ; 66: 123-136, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-33872780

20.

HipBA-promoter structures reveal the basis of heritable multidrug tolerance.

Schumacher, Maria A; Balani, Pooja; Min, Jungki; Chinnam, Naga Babu; Hansen, Sonja; Vulic, Marin; Lewis, Kim; Brennan, Richard G.

Nature ; 524(7563): 59-64, 2015 Aug 06.

Artigo em Inglês | MEDLINE | ID: mdl-26222023

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